‘What does best in class look like?’. This report shares key insights from a MAPS Annual Meeting workshop in March 2019, and provides further context with interviews and case studies from Medical Affairs colleagues who have first-hand experience of setting up and progressing a Field Medical Center of Excellence (CoE). Here we explore different Field Medical CoE models and key considerations for the different approaches taken; discuss the key success factors and also the challenges when setting up a Field Medical CoE; and provide food for thought for companies who may be considering setting up a CoE to learn from companies who are further along the journey.